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Medical Science Liaison (MSL): All You Need To Know

The Medical Science Liaison (MSL) role has become one of the most important customer focused roles within the pharmaceutical/biotech industry and this has led to a massive increase in the MSL work force globally. As a consequence, the supply of aspirant MSLs has increased as well, and companies are rising the MSL entry bar and many are now demanding a terminal degree as a minimum. The biggest challenge for many aspirant MSLs and even people in the pharmaceutical/biotech industry is to fully comprehend what an MSL does on a day to day basis.


The MSL has a strong scientific and/or clinical background and is the disease and drug expert within the medical (affairs) department of the pharmaceutical/biotech company. The MSL focusses on one to several diseases often grouped within the same disease area (i.e. oncology, hematology, auto-immune disease). Because of the MSL’s strong scientific and clinical knowledge, the MSL is the first point of contact to answer any complex questions from the internal stakeholders (their colleagues). This could be about: the mode of action of the drugs; disease related questions; the treatment decisions clinicians make and what drugs to use and when; the patient journey on how patients get diagnosed and treated; management of adverse events and questions about clinical trials from the company (and the competitors). This means that the MSL must be up-to-date on the latest literature and reading, presenting and discussing clinical topics is something an MSL needs to enjoy.

Terminal degree requirements for MSL

The MSL works at the interface between the internal stakeholders and the external stakeholders in the field – called Key Opinion Leaders (KOLs). KOLs – broadly defined as the clinical leaders in their disease area – can be heads of departments at teaching hospitals, heads of pharmacies, professors of medicine, the CEO of a patient organization, physicians involved in pharmaceutical clinical trials and sometimes clinical scientists. In short, MSLs work with many influential stakeholders in a disease area and must therefore be excellent communicators.

Many MSLs work in the pre-approval stage of the drug – i.e. the drug is not allowed to be sold yet. Therefore, MSLs are oftentimes closely involved in clinical trials and work with the KOLs who are involved in these clinical trials and using the drug often for the first time. The hope is that these new drugs will do better/have less side effect/ or are more convenient than the so-called standard of care treatment. Many MSL also have drugs in their portfolio that are already on the market and a sales team is present to sell the drug. Further clinical development might (not) be ongoing, and the role substantially changes compared to when you are working on a pipeline drug.

What does an MSL discuss with the KOLs? An MSL will mostly use clinical papers and international conference material to share with their KOLs. During those meetings, the MSL includes important questions from the internal stakeholder. These questions could be around: the future clinical development of the drug (in new indications); registration of the drug; reimbursement of the drug; gaps in medical education of the general clinicians on the disease/your drug; companion diagnostics for your drug; and competitive (dis)advantages of your drugs, to just name a few. The MSL then brings these crucial insights to the internal stakeholders that will help them form the best strategy to make this drug a clinical success for the patient, the treating doctor and the company.


Having a strong scientific and/or clinical background and strong personal and communication skills is therefore essential for an MSL. Because of the highly scientific and clinical nature of the MSL job – without you having to directly sell anything – the MSL role has become THE job of choice for many scientifically and clinically trained people such as pharmacist/MSc/PhDs/PharmDs and MDs. The combination of being a disease expert, reading clinical papers, discussing the science with top clinicians in the field, having that autonomy in your role and being able to travel a bit (across the globe to international conferences) was for me the ideal science job outside academia, while at the same time being able to influence how patients are being treated and will be treated in the future with the most innovative new drugs (soon to be) on the market.



Dr Martijn Bijker, PhD MSc

Founder of “from SCIENCE to PHARMA” – the most comprehensive global online Medical Science Liaison (MSL) training platform; helping Bachelors, Masters, PhDs, MDs, and PharmDs to maximize their chances of becoming an MSL.
Martijn’s LinkedIn profile

Medical Science Liaison (MSL): All You Need To Know last edit: 2017-07-22T18:29:19+00:00 da fromsciencetopharma
  • Paul Labeodan
    Posted 25 July 2017 21:19 0Likes

    Dr Bijker, thanks for your article. I am an MD and trying to enter the MSL world. Do you have any advise ?

    • fromsciencetopharma
      Posted 25 July 2017 21:54 0Likes

      Thank you for your reply and interest to become an MSL. We have a free MSL webinar on “How to break into the MSL role without experience”.
      You can sign up for the webinar on our website AND you will then receive a link to the recording afterwards as well
      Please let me know how you go with it and please follow us on LinkedIn (Martijn B) to hear more great content in the future.
      Talk to you soon.
      Kind regards,

    • YAHYA
      Posted 19 February 2018 16:37 0Likes

      dis you enroll in MSL training? which the best training centre online that has a credintially recognized certificate in Canada/ USA?

  • Dilruba Ahmed
    Posted 26 July 2017 6:14 0Likes

    Thanks Martijn for a rich article.
    I wonder if it is possible to start a career as an MSL right after finishing PhD in Molecular Biology. It seems that almost all the companies want MD with a PhD.
    I have studied Pharmacy and then did a PhD in Cancer Biology and would like a start a career as an MSL which seems very difficult at the moment.
    By the way I have signed up for the upcoming webinar, can not wait to know more ?
    Best regards,

  • fromsciencetopharma
    Posted 28 July 2017 7:17 0Likes

    Hi Dilruba,
    Thank you for your message. It depends on the country what the qualification requirements are. Some countries (and companies) have a preference for MDs others PhDs and some don’t mind at all.
    Having a pharmacy background will give you a competitive edge as you have a better understanding of the drugs, AE reporting, and healthcare/hospital system etc.
    oftentimes the CV from a PhD looks too academic and they don’t get any traction when they apply.
    We will discuss more tomorrow in the webinar. Look forward to having you there tomorrow.
    Talk soon.

  • Sanil Sansar
    Posted 13 August 2017 8:59 0Likes

    Thank you Martijn. You keep helping me

      Posted 13 August 2017 17:29 0Likes

      Dear Sanil,
      My pleasure. It is always good to hear we are able to help people.
      Kind regards

  • Isabel
    Posted 16 January 2018 3:55 0Likes

    Thank you Martijn great article as I contemplate on career change into Pharma. Definitely registering for your next Webnar.

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